The author is frustrated.
He is frustrated because even after depicting a man performing oral sex on a female multiple times in his comic strip, he has not yet successfully attracted a mate. Even after endlessly proving to female readers that he cares deeply for their feelings, and will bend-over backwards to please them - he still does not have a girlfriend. He fights for them. They do not call. He praises their intelligence and strength. They will not remove their clothing. He creates diagrams, graphs, math jokes and homographic puns that perfectly describe his feelings for them. They will not let him touch their breasts. He is frustrated.
He also refers to the movie Avatar, to ensure that some geek pop culture is still present in the comic strip.